Thyroid tests tell your healthcare provider how well your thyroid gland works. If a doctor is concerned about your thyroid function, they may recommend a series of blood tests to identify levels of hormones produced in the thyroid. Types of thyroid tests include blood tests, imaging tests and nuclear medicine tests. Read on to know more.
Thyroid tests are blood tests that measure the levels of thyroid hormones or thyroid-stimulating hormones (TSH) in your bloodstream. The available tests include the T3, T3RU, T4, and TSH. These tests are used to assess the functioning of your thyroid gland, a small gland located in the lower-front part of your neck. The gland plays a crucial role in regulating various bodily functions, including metabolism, energy generation, and mood.
Common thyroid tests include:
This test measures the level of thyroid stimulating hormone in your blood. High TSH levels may indicate an underactive thyroid (hypothyroidism), while low TSH levels may suggest an overactive thyroid (hyperthyroidism).
This test measures the level of free thyroxine, a thyroid hormone circulating inn your bloodstream. Abnormal levels can indicate thyroid disorders. If fT4 is too high, it indicates hyperthyroidism; if it is too low, it means hypothyroidism. This test is considered more accurate than Total T4.
Too low total T4 indicates hypothyroidism, and too high means hyperthyroidism. Total T4 is normally tested in pregnant patients.
This test measures the level of free triiodothyronine, another thyroid hormone that is used mostly by your liver. Too low fT3 means you have hypothyroidism, and too high indicates hyperthyroidism. Free T3 test is not considered reliable as it measures only T3 floating freely in our blood.
This test measures all T3 in your body, even those which are unusable because it’s already bound to a protein. If the T3 levels are abnormally high, it can cause an autoimmune disorder called Grave’s disease.
This test checks for anti-thyroid peroxidase (TPO) antibodies and anti-thyroglobulin antibodies which are used to diagnose autoimmune thyroid disorders such as Hashimoto’s thyroiditis.
Reverse T3 is an inactive form of T3 and is produced when T4 is metabolised. Too much or too little rT3 can indicate inflammation or trauma after surgery or in case of malnutrition.
While this is not a blood test, a thyroid ultrasound uses sound waves to create images of your thyroid gland. It helps in evaluating the size, shape, and texture of the thyroid and detecting any abnormalities or nodules.
Our body uses thyroid hormones for energy and proper functioning of organs and muscles. If thyroid gland produces too much or too little thyroid hormones, you will suffer from hyperthyroidism or hypothyroidism respectively. Having either of the two conditions can cause hair loss as thyroid hormones help develop and maintain hair follicles. Autoimmune disorders due to thyroid dysfunction can also lead to hair loss.
Test | Result | What does it indicate? |
TSH | <0.1 milliunits per litre (mU/L) 0.1-0.5 mU/L 0.4-4.5 mU/L 4.7-10 mU/L >10 mU/L | Overactive thyroid problem with symptoms Subclinical overactive thyroid problem Normal range Subclinical hypothyroidism Low thyroid problem that does not show symptoms |
Total T3 | 100-200 ng/dL <100-200 nanograms per decilitre (ng/dL) >200 ng/dL | Normal range Indicates hypothyroidism as the levels are lower than normal Indicates hyperthyroidism as the levels are high |
Free T3 (fT3) | 130-450 pg/dL, or 2.0 to 7.0 pmol/L <130 picograms per decilitre (pg/dL) or 2.0 picomoles per litre (pmol/L) >450 pg/dL, or 7.0 pmol/L | Normal range Indicates hypothyroidism Indicates hyperthyroidism |
Total T4 | 5.0-12.0 ug/dL <5.0 ug/dL (micrograms per decilitre of blood) >12 ug/dL | Normal range Indicates hypothyroidism Indicates hyperthyroidism |
Free T4 (fT4) | 0.9 – 1.8 ng/dL or 12 to 30 pmol/L <0.9 ng/dL or 12 pmol/L >1.8 ng/dL or 30 pmol/L | Normal range Indicates hypothyroidism Indicates hyperthyroidism |
TPO antibodies (TPOAb) | Negative Positive | Normal, no antibodies found, symptoms probably aren’t caused by autoimmune disease Indicates autoimmune disease |
Reverse (rT3) | 10-24 ng/dL <10 ng/dL >24 ng/dL | Normal range Can indicate hypothyroidism Can occur in critically ill patients |
Several factors can affect the thyroid function tests and may lead to inaccurate results. Some of the key factors include:
It’s crucial to inform your healthcare provider about any medications you are taking before undergoing the tests as certain medications can affect thyroid function test results.
For accurate results, thyroid function tests are often performed in the morning after an overnight fast. This is because thyroid hormone levels can fluctuate throughout the day, TSH in particular as it follows a diurnal rhythm, with higher levels in the early morning.
If the patient hasn’t eaten for an extended period, the fasting status can affect thyroid hormone levels.
Excessive iodine intake can interfere with thyroid function tests, especially radioactive iodine uptake tests.
Pregnancy can impact thyroid hormone levels as these women may have higher levels of thyroid-binding protein, which can affect total thyroid hormone measurements.
Significant stress or acute illness can temporary alter thyroid hormone levels.
Thyroid hormone levels can vary with age and gender. Older adults may have different reference ranges for thyroid function tests.
Thyroid tests are essential for diagnosing thyroid disorders, monitoring thyroid function, and guiding treatment decisions. If you have concerns about your thyroid health, it’s important to consult a healthcare professional for proper evaluation and guidance.
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Source: singlecare, my.clevelandclinic, medlineplus, webmd, healthline, everydayhealth
Disclaimer: This blog provides general information and discussions about health and related subjects. The information and other content provided in this blog, website or in any linked materials are not intended and should not be considered, or used as a substitute for, medical advice, diagnosis or treatment. Kindly contact your Doctor before starting a new medicine or health regime.
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Published on November 22, 2023